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 Title:

      Antimicrobial and Cytotoxic activity of the alkaloids of Amlaki (Emblica officinalis).

 Authors:

      Md. Shafikur Rahman , Maruf Mohammad Akbor, Md. Amran Howlader, Abdul Jabbar

 Publication Area:

      Pharmacy

 Abstract:

      Alkaloids are important sources of drug that’s why we have conducted our research to find the biological activity of the alkaloids of a plant that is the Amlaki. Alkaloids were extracted from the methanolic extract of the fresh ripe fruits of Amlaki (Emblica officinalis) through solvent-solvent partitioning method with n-hexane and chloroform. The chloroform soluble fraction of the crude methanolic extract of the ripe fruits of Amlaki containing alkaloids was subjected to antimicrobial activity and brine shrimp lethality bioassay for observing cytotoxic activity. The chloroform soluble fraction of the methanolic extract exhibited significant antimicrobial activity against some Gram positive and Gram negative pathogenic bacteria and strong cytotoxicity having a LC50 of 10.257±0.770 µg ML-1. It is concluded that the chloroform soluble fraction of the ripe fruits of Amlaki containing alkaloids are biologically active.

 Source: Pakistan Journal of Biological Science , 12 (16):1152-1155
 Year: 2009

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